Computational Psychiatry & Decision-making

Other Research Topics



The documents distributed here have been provided as a means to ensure timely dissemination of scholarly and technical work on a noncommercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.


  • Model-based and model-free control predicts alcohol consumption developmental trajectory in young adults - a three-year prospective study
  • Chen H, Belanger MJ, Mojtahedzadeh N, Nebe S, Kuitunen-Paul S, Sebold M, Garbusow M, Huys QJM, Heinz A, Rapp MA and Smolka MN
  • Biological Psychiatry (2021) In Press
  • Background: A shift from goal-directed toward habitual control has been associated with alcohol dependence. Whether such a shift predisposes pathological drinking is not yet clear. We investigated how goal-directed and habitual control at age 18 predict alcohol use trajectories over the course of three years. Methods: Goal-directed and habitual control, as informed by model-based and model-free learning, were assessed with a two-step sequential decision-making task during fMRI in 146 healthy 18-year-old male adults. Two key drinking variables were used to model the three-year alcohol use developmental trajectory: a consumption score from the Alcohol Use Disorders Identification Test (AUDIT-C; assessed every six months) and a binge drinking score (gram alcohol/occasion; assessed every year). We applied a latent growth curve model to examine how model-based and model-free control predicted the drinking trajectory. Results: The drinking behavior was best characterized by a linear trajectory. The model-based behavioral control was negatively associated with the development of the binge drinking score; the model-free reward prediction error (RPE) BOLD signals in the ventromedial prefrontal cortex and the ventral striatum predicted a higher starting point and steeper increase of the consumption score over time, respectively. Conclusions: We found that model-based behavioral control was associated with the binge drinking trajectory, while the model-free RPE signal was closely linked to the consumption score development. These findings support the idea that a shift from model-based to model-free control might be an important individual vulnerability in predisposing hazardous drinking behavior.