Research

Computational Psychiatry & Decision-making

Other Research Topics

 

Copyright

The documents distributed here have been provided as a means to ensure timely dissemination of scholarly and technical work on a noncommercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstracts

  • doi Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use
  • Hao C, Nebe S, Mojtahedzadeh N, Kuitunen-Pauls S, Garbusow M, Schad D, Rapp M, Huys QJ, Heinz A, Smolka M
  • Addiction Biology (2020)
  • Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking, and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N=191) were instructed to "collect good shells" and "leave bad shells" during the presentation of appetitive (monetary reward), aversive (monetary loss), or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and fMRI brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, i.e. increased ER when Pavlovian cues and instrumental stimuli were in conflict compared to congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response, and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), along with their altered interplay may contribute to poor interference control in the high-risk drinkers.