Research

Computational Psychiatry & Decision-making

Other Research Topics

 

Copyright

The documents distributed here have been provided as a means to ensure timely dissemination of scholarly and technical work on a noncommercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

Abstracts

  • doi pdf The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
  • Berwian IM, Wenzel J, Kuehn L, Schnuerer I, Kasper L, Veer IM, Seifritz E, Stephan KE, Walter H, Huys QJM
  • bioRxiv
  • Background: The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. Method: rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants who were intent on discontinuing their medication. Patients went on to discontinue their antidepressants, were assessed a second time either before or after discontinuation and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. Results: 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. Seed-based analysis failed to reveal differences in functional connectivity between patients and controls; and between relapsers and non-relapsers. Although overall there was no effect of antidepressant discontinuation, amongst non-relapsers discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex. Conclusion: No abnormalities in resting-state functional connectivity were detected in remitted patients on antidepressant medication. Resilience to relapse after open-label antidepressant discontinuation was associated with changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network.